Growing up in Chicago, my kitchen was always the heart of our home. I can still picture my babcia’s hands expertly kneading dough for her famous pierogi while my mom orchestrated a symphony of pots and pans, filling our home with the rich aromas of love and tradition. Now, as a mother of two, I cherish these memories and love creating new ones with my own family. One of our absolute favorites is Crockpot Mississippi Meatloaf. It’s a delightful twist on a classic comfort dish, combining the savory flavors of a traditional meatloaf with the tangy zest of Mississippi pot roast. This dish has become a staple in our home, offering the warmth of my childhood with a modern, flavorful twist.
Why You’ll Love This Recipe
There are countless reasons to fall in love with Crockpot Mississippi Meatloaf. For starters, it’s incredibly easy to make. With just a handful of ingredients and a crockpot, you can create a meal that feels like a warm hug on a chilly Chicago evening. This recipe is perfect for busy families like mine, as it requires minimal prep and cooks to perfection while you go about your day. Plus, it’s a great way to sneak in some veggies for the kids without them even noticing! The meatloaf is tender, juicy, and packed with flavor, thanks to the unique blend of ranch dressing mix and pepperoncini peppers. It’s the ultimate crowd-pleaser, whether you’re serving it at a family dinner or a casual gathering with friends.
Ingredients
- 2 pounds ground beef
- 1 packet ranch dressing mix
- 1 packet au jus gravy mix
- 1/2 cup breadcrumbs
- 1/4 cup milk
- 2 eggs
- 1/2 cup chopped onion
- 1/4 cup chopped bell pepper
- 5-6 pepperoncini peppers, sliced
- 1/4 cup pepperoncini juice
- Salt and pepper to taste

Step-by-Step Instructions
- In a large bowl, combine ground beef, ranch dressing mix, au jus gravy mix, breadcrumbs, milk, eggs, chopped onion, and bell pepper. Mix until well combined.
- Shape the mixture into a loaf and place it in the crockpot.
- Top the meatloaf with sliced pepperoncini peppers and pour the pepperoncini juice over the top.
- Cover and cook on low for 6-7 hours or until the meatloaf is cooked through and reaches an internal temperature of 160°F.
- Let the meatloaf rest for a few minutes before slicing and serving.
What Makes This Recipe Special
- Quick and easy to prepare
- Packed with flavor and nutrition
- Perfect for any occasion
- Customizable to your taste preferences
- Budget-friendly ingredients
Expert Tips for Success
For the best results, use a meat thermometer to ensure your meatloaf is perfectly cooked. This prevents it from drying out or being undercooked. If you prefer a spicier kick, feel free to add more pepperoncini peppers or a dash of hot sauce. To make slicing easier, let the meatloaf rest for about 10 minutes after cooking. This allows the juices to redistribute, making each slice tender and juicy.
Amazon Affiliate Cooking Tools
When I make this recipe, I always rely on a few trusty kitchen tools to make the process smoother. My go-to tool is the MOSFiATA 8″ Professional Chef’s Knife for chopping onions and peppers with precision. The MEATER SE Smart Meat Thermometer is invaluable for ensuring the meatloaf is cooked to perfection without having to guess. And for mixing the ingredients, I love using the Silicone Utensils Set – 12 pcs, which makes cleanup a breeze.

Variations and Substitutions
There are plenty of ways to customize this Crockpot Mississippi Meatloaf to suit your tastes. For a gluten-free version, simply swap the breadcrumbs for gluten-free breadcrumbs or crushed gluten-free crackers. If you’re looking to cut back on red meat, ground turkey or chicken can be used as a substitute for ground beef. For an extra burst of flavor, try adding a tablespoon of Worcestershire sauce or a splash of balsamic vinegar to the meat mixture. You can also experiment with different types of cheese, such as mozzarella or cheddar, for a cheesy twist.
Serving Suggestions
This meatloaf pairs beautifully with classic sides like mashed potatoes or roasted vegetables. For a lighter option, serve it with a crisp green salad or steamed broccoli. A warm, crusty loaf of bread is perfect for soaking up the delicious juices. To complete the meal, consider serving a glass of your favorite red wine or a refreshing iced tea. And for dessert, my grandmother Elizabeth’s apple cake is a delightful way to end the meal on a sweet note.

FAQs
Can I make this meatloaf in the oven instead of a crockpot?
Yes, you can bake the meatloaf in a preheated oven at 350°F for about 1 hour, or until the internal temperature reaches 160°F.
How can I store leftovers?
Leftover meatloaf can be stored in an airtight container in the refrigerator for up to 3 days. You can also freeze slices for up to 3 months. Simply reheat in the oven or microwave before serving.
What if I don’t have pepperoncini peppers?
If you can’t find pepperoncini peppers, banana peppers or jalapeños can be used as a substitute, though they will alter the flavor slightly.
Final Thoughts
Creating this Crockpot Mississippi Meatloaf has become a cherished tradition in our home. It’s a dish that brings my family together, filled with laughter and love, as we gather around the table to enjoy a meal that warms our hearts and fills our bellies. I hope this recipe brings the same joy and comfort to your home as it does to ours. Don’t forget to share your results and enjoy cooking with love and humor!
Dynamic Related Recipe Section
I hope you loved making this Crockpot Mississippi Meatloaf—it’s like a warm hug from my Chicago kitchen to yours. If you’re looking for more comforting recipes to try, check out these favorites: Creamy Chicken Casserole, Classic Beef Stew, Homemade Mac and Cheese, and Garlic Mashed Potatoes. Join us on our Facebook Page and Facebook Group—and don’t forget to follow on Pinterest for daily inspiration!
⭐ 5 from 1 voteIngredients
Directions
- In a large bowl, combine ground beef, ranch dressing mix, au jus gravy mix, breadcrumbs, milk, eggs, chopped onion, and bell pepper. Mix until well combined.
- Shape the mixture into a loaf and place it in the crockpot.
- Top the meatloaf with sliced pepperoncini peppers and pour the pepperoncini juice over the top.
- Cover and cook on low for 6-7 hours or until the meatloaf is cooked through and reaches an internal temperature of 160°F.
- Let the meatloaf rest for a few minutes before slicing and serving.
